Determination of Chemical Groups and Investigation of Anthelmintic, Cytotoxic, and Antibacterial Activities of Leaves of Cinnamomum Tamala (Family: Lauraceae)

Abstract

The present study was conducted for the characterization of possible chemical groups, evaluation of anthelmintic, cytotoxic and antibacterial activities of crude methanolic extract of leaves of Cinnamomum tamala. The study revealed the presence of alkaloids, reducing sugar, tannin, amino acids, glycosides and steroid in the crude extract. The extract showed very potent anthelmintic activity while compared with the standard albendazole. To investigate the cytotoxic activity, brine shrimp lethality bioassay was conducted, and the extract showed significant activity while compared with the standard vincristine sulphate (LC50 value 1.007 and 0.839μg/ml respectively). To evaluate the antibacterial activity, disc diffusion method was followed, and the extract showed activity against Bacillus subtilis, Staphylococcus aureus, Bacillus cereus, and Vibrio cholera, and resistant to Escherichia coli and Salmonella typhi.