Design and Development of Alfuzosin Hydrochloride Floating Tablet

Abstract

The purpose of present research was to develop and optimize prolong release floating tablet of alfuzosin hydrochloride which has narrow absorption window in proximal intestine to improve patient compliance and therapeutic efficiency in the treatment of benign prostatic hyperplasia. The system was designed to provide floating tablet by using hydroxyl propyl methyl cellulose. Different batches of tablets containing 10 mg of alfuzosin were prepared using by direct compression technique. Formulations were prepared using 32 factorial design and the type of polymer and diluents was taken as independent variables. The percentage drug release at 1,6,12 and 20 hours; floating lag time; diffusion exponent (n) and release rate constant were selected as dependent variable. Formulations were evaluated for their physical properties, drug content and in vitro drug release. All formulations had good physical integrity. Drug release from floating tablet was carried out for the 24 hour and showed that the release rate was highly significant to different grades of Methocel and type of diluents. Formulation batch F6 gave the continuous drug release for the 24 hours with Fickian diffusion type drug release mechanism and considered as optimum based on pre and post compression evaluations of the formulations. Study shows that floating drug delivery system is very useful system for prolong drug release control of highly soluble drugs.